Epidural clonidine employed as an adjunct to local anesthetics has 3 diverse mechanisms of action. Initially, the stimulation of alpha-2-receptors from the dorsal horn cuts down soreness transmission. Secondly, clonidine can cause local vasoconstriction that limits vascular elimination of local epidural anesthetics. Jun ten, 2024 · If clonidine therapy https://simonj726xxv4.wikigop.com/user