Limb-threatening or significant limb ischemia (CLI) is manifested by chronic (over two weeks) ischemic rest discomfort, ischemic wounds or tissue reduction, or gangrene in one or both of those legs. Ischemic rest ache usually happens quickly after falling asleep; the affected person is awakened by burning ache or numbness inside https://www.sgvascularctr.com/treatment-of-peripheral-artery-disease-pad-in-singapore-a-comprehensive-guide/