Chemotherapy was potentiated by E7449 and one agent experienced significant antitumor activity in BRCA-deficient xenografts. Furthermore, E7449 inhibited Wnt/β-catenin signaling in colon cancer cell traces, very likely by way of TNKS inhibition. In keeping with this possibility, E7449 stabilized axin and TNKS proteins resulting in β-catenin de-stabilization and significantly altered https://barrettu752lqu5.bloggactif.com/profile