Cure of a number of myeloma cells with VLX1570 induced the accumulation of proteasome-bound substantial molecular excess weight polyubiquitin conjugates and an apoptotic response. Sensitivity to VLX1570 was moderately afflicted by altered drug uptake, but was unaffected by overexpression of BCL2-spouse and children proteins or inhibitors of caspase activity. At https://noelf443cvn5.wikiannouncement.com/user